GT Metabolic™ Magnetic Anastomosis System

GT Metabolic™ Magnetic Anastomosis System

GT Metabolic has developed and is ready to launch a proprietary magnetic compression anastomosis technology. The incisionless, sutureless, staple-free technique is designed to revolutionize how surgeons achieve anastomosis.

Details

Technique Used In Clinical Studies:
Magnetic System Side-to-Side Compression Anastomosis Duodeno-ileostomy

Step 1

The patient swallows the first magnet in the outpatient department. The magnet travels into the stomach and the duodenum and reaches the ligament of Treitz in about two hours.

Step 2

Once the patient is under anesthesia in the OR, a marker is placed in the ileum 250cm from cecum laparoscopically

Step 3

The laparoscopic positioning device (LPD) is used to capture the magnet and direct it distally through the jejunal lumen to the marked position in the ileum, 250 cm from the ileocecal valve.

Step 4

At the same time, the second magnet is transported orogastrically by a flexible endoscopic catheter into the
antrum and then is brought into the duodenum ~2cm
after the pylorus. This is the intended magnet fusion
site

Step 5

The distal magnet in the ileum is elevated antecolic
and brought together with the second magnet in the
post-pyloric duodenum.

Step 6

The second (proximal) magnet is released to self-align
with the first (distal) magnet through the intestinal
walls. The endoscope and LPD are withdrawn.
Peterson’ s defect is closed.

Step 7

In several days, the two magnets are fully fused after
compressing and sloughing the tissue between them.
The magnets detach several weeks later from the
duodeno-ileal site and are expressed naturally.

Step 8

Food flows through the duodenal lumen, and also through the patent anastomosis into the ileal lumen. The anastomosis is extremely durable after 3-4 weeks.

Step 9

After the procedure, patients are carefully monitored with special attention to hemodynamic conditions and cardiac rhythm for a minimum of 24 hours. Successful placement of the MAGNET System is confirmed radiologically by abdominal x-ray, and fluoroscopically, using barium or gastrographin on postoperative day 1. Patients meet with a dietician or nutritionist prior to discharge to review the post-procedure diet.

Surgeon Early Observations

Product Technology

These videos include references to the use of a surgical device and the opinions of the individual presenter. The videos may also include references to medical devices still in development or available for investigational use only and represents scientific exchange.

GT Metabolic™ Mag DI™ System

MAGDI™ MAGNETS

  • The 40mm or 50mm Parylene-C coated neodymium magnet is encased in a titanium shell with a PGLA bio-fragmentable flange.
  • A delivery system connect/release
    mechanism is located at one end of the magnet.
  • The device is intended for use for side-to-side duodeno-ileal anastomosis in minimally invasive
    and laparoscopic surgery.
  • Sterile; disposable.

MAGDI™ DELIVERY SYSTEM

  • The 40mm or 50mm Parylene-C coated neodymium magnet is encased in a titanium shell with a PGLA bio-fragmentable flange.
  • A delivery system connect/release
    mechanism is located at one end of the magnet.
  • The device is intended for use for side-to-side duodeno-ileal anastomosis in minimally invasive
    and laparoscopic surgery.
  • Sterile; disposable.

MAGDI™ LAPAROSCOPIC POSITIONING DEVICE

  • The 41cm-long reusable laparoscopic
    positioning device (LPD) is
    compatible with a 12mm trocar.
  • The instrument is comprised of a Paralene-C coated neodymium magnet encased in a titanium housing, non-magnetic shaft and positioning handle detailing the strength of the instrument.
  • Offered in five magnetic strengths, the LPD provides surgeon with options depending on patient’s bowel morphology. (A higher number indicates greater magnetic strength.)
  • The LPD is used to position the linear magnetic technology (LMT) at the desired anastomotic site.
  • Reusable; requires sterilization.

MAGDI™ MAGNETIC RETRIEVAL DEVICE

  • The 40mm or 50mm Parylene-C coated neodymium magnet is encased in a titanium shell with a PGLA bio-fragmentable flange.
  • A delivery system connect/release
    mechanism is located at one end of the magnet.
  • The device is intended for use for side-to-side duodeno-ileal anastomosis in minimally invasive
    and laparoscopic surgery.
  • Sterile; disposable.

The Founders of the Technology

GT Metabolic founders Thierry Thaure and Michel Gagner, MD, are renowned global experts in the area of bariatric and metabolic procedures. They’ve led the GT Metabolic team in engineering a magnetic compression solution called delayed anastomosis technology (DAT) that surgeons can use to create consistent anastomosis while helping minimize potential complications.

Thierry Thaure
CEO & Co-founder

Michel Gagner, MD
CMO & Co-founder

Sources:

1. De Novo marketing authorization DEN240013. MagDI™ System for side-to-side duodeno-ileal anastomosis granted De Novo marketing authorization from the U.S. Food and Drug Administration (FDA). 2 July 2024. The second-generation MagDI™ System with the 40mm DI Magnet and 50mm DI Magnet received U.S. FDA 510(k) clearances in October 2024 and February 2025 respectively (K242086, K243359).

2. Gagner, M., Almutlaq, L., Cadiere, G.-B., Torres, A. J., Sanchez-Pernaute, A., Buchwald, J. N., & Abuladze, D. (2023). Side-to-side magnetic duodeno-ileostomy in adults with severe obesity with or without type 2 diabetes: Early outcomes with prior or concurrent sleeve gastrectomy. Surgery for Obesity and Related Diseases. https://doi.org/10.1016/j.soard.2023.10.018

3. Gagner, M., Abuladze, D., Koiava, L. et al.First-in-Human Side-to-Side Magnetic Compression Duodeno-ileostomy with the Magnet Anastomosis System. OBES SURG 33, 2282–2292 (2023). https://doi.org/10.1007/s11695-023-06708-x

4. Gagner M, Cadiere GB, Sanchez-Pernaute A, Abuladze D, Krinke T, Buchwald JN, Van Sante N, Van Gossum M, Dziakova J, Koiava L, Odovic M, Poras M, Almutlaq L, Torres AJ. Side-to-side magnet anastomosis system duodeno-ileostomy with sleeve gastrectomy: early multi-center results. Surg Endosc. 2023 Aug;37(8):6452-6463. doi: 10.1007/s00464-023-10134-6. Epub 2023 May 22. PMID: 37217682; PMCID: PMC10202352.

5. Gagner, M., Abuladze, D., Buchwald, J., et al. First-in-Human Side-to-Side Duodenoileal Bipartition for Weight Loss and Type 2 Diabetes with the Swallowable Biofragmentable Magnetic Anastomosis System. JACS 241(2):p 146-159, August 2025. https://doi.org/10.1097/XCS.0000000000001384.

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